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Oxidation of potassium channel in cells linked to loss of neuronal function in aging

September 02, 2017

Ischemia-reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia. The absence of oxygen and nutrients from blood creates a condition in which restoration of circulation results in inflammation and oxidative damage rather than restoration of normal function.

The RED-CABG Phase 3 Trial

The RED-CABG (Reduction in cardiovascular Events by acaDesine in subjects undergoing CABG) Trial is a randomized, double-blind, placebo-controlled, multinational, Phase 3 study of 7500 high-risk patients undergoing on-pump CABG. High-risk patients are defined as either female, or males with a previous history of CABG surgery, heart attack, stroke, low left ventricular ejection fraction, or diabetes mellitus. Patients will be randomized to either acadesine or placebo IV infusion started before anesthesia and continued for a total of seven hours through surgery and postoperatively. The primary endpoint is a composite of all-cause death, severe left ventricular dysfunction requiring mechanical support, or stroke at post-operative day 28. All-cause death will also be assessed at six months.

schering-plough/