AlgemeneGezondheid.Org

Cervical ripening that instigates preterm birth is distinct from normal term labor

April 26, 2017

"When patients present in preterm labor, we don't have a lot of therapy to stop the labor," she said.

UT Southwestern researchers compared preterm birth models in mice. They injected lipopolysaccharide (LPS) to promote infection-like conditions and an inflammatory response in one model. In the other, they administered mifepristone (RU486) to simulate the withdrawal of the gestation-supporting hormone progesterone, which normally takes place at the end of a pregnancy.

Researchers report that cervical changes in inflammation-induced conditions are caused by an influx of white blood cells and an increased expression of pro-inflammatory markers with no increase in the expression of genes induced in term ripening. Preterm ripening induced by progesterone withdrawal results from the combined activation of processes that occur during term ripening and shortly postpartum.

"These findings, if translatable in women, suggest one therapy may not be effective for all preterm births, and that early identification of the cause of prematurity is necessary to determine the correct therapy," Dr. Mahendroo said.

Source: www.utsouthwestern/home/news/index.html